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- Title
ES cells for troubled hearts.
- Authors
Rubart, Michael; Field, Loren J.
- Abstract
The article presents a study that investigates the benefits of cardiomyocytes derived from human embryonic stem cells in rat models of myocardial infarction. Using echocardiography and magnetic resonance imaging, modest decreases in cardiac pump function were observed after ischemia/reperfusion injury that were commensurate with infarct size. The authors have shown that transplantation of hES cell-derived cardiomyocytes can attenuate the progressive dysfunction and adverse remodeling that occurs in rats after myocardial infarction.
- Subjects
HEART cells; EMBRYONIC stem cells; MYOCARDIAL infarction; CORONARY disease; ECHOCARDIOGRAPHY; DIAGNOSTIC ultrasonic imaging; CARDIAC imaging; LABORATORY rats; ANIMAL models in research
- Publication
Nature Biotechnology, 2007, Vol 25, Issue 9, p993
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt0907-993