We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Riboswitches as antibacterial drug targets.
- Authors
Blount, Kenneth F.; Breaker, Ronald R.
- Abstract
New validated cellular targets are needed to reinvigorate antibacterial drug discovery. This need could potentially be filled by riboswitches—messenger RNA (mRNA) structures that regulate gene expression in bacteria. Riboswitches are unique among RNAs that serve as drug targets in that they have evolved to form structured and highly selective receptors for small drug-like metabolites. In most cases, metabolite binding to the receptor represses the expression of the gene(s) encoded by the mRNA. If a new metabolite analog were designed that binds to the receptor, the gene(s) regulated by that riboswitch could be repressed, with a potentially lethal effect to the bacteria. Recent work suggests that certain antibacterial compounds discovered decades ago function at least in part by targeting riboswitches. Herein we will summarize the experiments validating riboswitches as drug targets, describe the existing technology for riboswitch drug discovery and discuss the challenges that may face riboswitch drug discoverers.
- Subjects
MESSENGER RNA; GENE expression; ANTIBACTERIAL agents; EFFECT of antibiotics on microorganisms; METABOLITES; DRUG development; BIOSYNTHESIS; THERAPEUTICS
- Publication
Nature Biotechnology, 2006, Vol 24, Issue 12, p1558
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt1268