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- Title
Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.
- Authors
Glenz, Karin; Bouchon, Bernadette; Stehle, Thomas; Wallich, Reinhard; Simon, Markus M; Warzecha, Heribert
- Abstract
Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)—the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants.
- Subjects
PLASTIDS; ORGANELLES; PHOTORECEPTORS; LOW density lipoproteins; GENETIC translation
- Publication
Nature Biotechnology, 2006, Vol 24, Issue 1, p76
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt1170