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- Title
Research Highlights.
- Authors
Aschheim, Kathy; Cervoni, Nadia; Defrancesco, Laura; Taroncher- Olden Burg, Gaspar; Zipkin, Mark
- Abstract
The article focuses on the biotechnological research. MicroRNA (miRNA) expression profiling could become an adjunct to mRNA expression profiling in diagnosing cancers. Compared with mRNAs, miRNAs--endogenous ~21-nucleotide noncoding RNAs involved in cell regulation--were found by the researchers not only to be more stable but also to show more diversity of expression in human cancers, enabling fewer to be tracked in diagnosis. Protein kinases represent an important class of targets for therapeutic intervention, given their pivotal role in many regulatory pathways. Three groups have independently developed similar culture systems for replicating complete hepatitis C virus (HCV) genomes and producing infectious HCV viral particles, whereas a fourth has produced infectious human papillomaviruses (HPV) in cell culture.
- Subjects
BIOTECHNOLOGY research; MESSENGER RNA; CANCER; PROTEIN kinases; DIAGNOSIS; HEPATITIS C virus
- Publication
Nature Biotechnology, 2005, Vol 23, Issue 7, p831
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt0705-831