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- Title
Turning aptamers into anticoagulants.
- Authors
Famulok, Michael
- Abstract
The article sites a study suggesting that an RNA-based anticoagulant aptamer and its RNA antidote represents a safer approach to anticoagulant therapy. Aptamers are short single-stranded oligonucleotides that fold into distinct three dimensional structures that recognize target molecules. The design of an aptamer-antidote pair is intuitive: each aptamer sequence inherently carries the prescription for its antidote. The aptamer-antidote pair appears to be advantageous compared with the most common anticoagulant-antidote pair used in clinical practice, namely heparin and its neutralizing polypeptide protamine.
- Subjects
ANTICOAGULANTS; RNA; ANTIDOTES; OLIGONUCLEOTIDES; HEPARIN; NUCLEOTIDES
- Publication
Nature Biotechnology, 2004, Vol 22, Issue 11, p1373
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt1104-1373