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- Title
Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx.
- Authors
Shiao, Jay C.; Mohamed, Abdallah S. R.; Messer, Jay A.; Hutcheson, Katherine A.; Johnson, Jason M.; Enderling, Heiko; Kamal, Mona; Warren, Benjamin W.; Pham, Brian; Morrison, William H.; Zafereo, Mark E.; Hessel, Amy C.; Lai, Stephen Y.; Kies, Merril S.; Ferrarotto, Renata; Garden, Adam S.; Schomer, Donald F.; Gunn, G. Brandon; Phan, Jack; Frank, Steven J.
- Abstract
Background The purpose of this study was to determine the impact of CT-determined pretreatment primary tumor volume on survival and disease control in T4a laryngeal squamous cell carcinoma (SCC). Methods We retrospectively reviewed 124 patients with T4a laryngeal cancer from 2000-2011. Tumor volume measurements were collected and correlated with outcomes. Results Five-year overall survival (OS) for patients with tumor volume ≥21 cm3 treated with larynx preservation (n = 26 of 41) was significantly inferior compared to <21 cm3 (42% vs 64%, respectively; P = .003). Five-year OS for patients with tumor volumes ≥21 cm3 in the cohort treated with total laryngectomy followed by radiotherapy (RT; n = 42 of 83) was not statistically significant when compared to <21 cm3 (50% vs 63%, respectively; P = .058). On multivariate analysis, tumor volume ≥21 cm3 was a significant independent correlate of worse disease-specific survival (DSS; P = .004), event-free survival ( P = .005), recurrence-free survival (RFS; P = .04), noncancer cause-specific survival ( P = .02), and OS ( P = .0002). Conclusion Pretreatment CT-based tumor volume is an independent prognostic factor of outcomes in T4a laryngeal cancer.
- Subjects
COHORT analysis; LARYNGEAL cancer; CANCER radiotherapy; CANCER treatment; SQUAMOUS cell carcinoma; STATISTICAL correlation
- Publication
Head & Neck, 2017, Vol 39, Issue 8, p1609
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24804