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- Title
Effects of Chronic Estrogen Treatment on Modulating Age-Related Bone Loss in Female Mice.
- Authors
Syed, Farhan A.; Mödder, Ulrike I. L.; Roforth, Matthew; Hensen, Ira; Fraser, Daniel G.; Peterson, James M.; Oursler, Merry Jo; Khosla, Sundeep
- Abstract
The article discusses research on female mice and how chronic estrogen treatment can affect modulation of age-related bone loss. Researchers ovariectomized and replaced the estrogen of female mice at 6 months then at 18 and 22 months. The study indicated the prevention of age-related reduction in cortical volumetric bone mineral density (vBMD) with lifelong estrogen treatment while younger mice had 42% decrease in lumbar spine bone volume/total volume (BV/TV) and maintenance of constant estorgen levels did not prevent bone loss.
- Subjects
ESTROGEN replacement therapy; BONE diseases; ANIMAL models in research; MINERALS in the body; SPINE diseases
- Publication
Journal of Bone & Mineral Research, 2010, Vol 25, Issue 11, p2438
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1002/jbmr.129