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Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example.
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- Rapid Communications in Mass Spectrometry: RCM, 2011, v. 25, n. 23, p. 3587, doi. 10.1002/rcm.5274
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Development of a biomarker assay for 3-indoxyl sulfate in mouse plasma and brain by liquid chromatography/tandem mass spectrometry.
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- Rapid Communications in Mass Spectrometry: RCM, 2009, v. 23, n. 13, p. 2061, doi. 10.1002/rcm.4111
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Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples.
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- Rapid Communications in Mass Spectrometry: RCM, 2006, v. 20, n. 14, p. 2215, doi. 10.1002/rcm.2580
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Matrix-assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue.
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- Rapid Communications in Mass Spectrometry: RCM, 2006, v. 20, n. 6, p. 965, doi. 10.1002/rcm.2397
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Investigation of the profiling depth in matrix-assisted laser desorption/ionization imaging mass spectrometry.
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- Rapid Communications in Mass Spectrometry: RCM, 2006, v. 20, n. 2, p. 284, doi. 10.1002/rcm.2259
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Optimizing an ultrafast generic high-performance liquid chromatography/tandem mass spectrometry method for faster discovery pharmacokinetic sample throughput.
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- Rapid Communications in Mass Spectrometry: RCM, 2005, v. 19, n. 20, p. 2905, doi. 10.1002/rcm.2147
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A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays.
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- Rapid Communications in Mass Spectrometry: RCM, 2005, v. 19, n. 18, p. 2643, doi. 10.1002/rcm.2102
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Development of a low volume plasma sample precipitation procedure for liquid chromatography/tandem mass spectrometry assays used for drug discovery applications.
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- Rapid Communications in Mass Spectrometry: RCM, 2005, v. 19, n. 15, p. 2131, doi. 10.1002/rcm.2040
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A fully automated nanoelectrospray tandem mass spectrometric method for analysis of Caco-2 samples.
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- Rapid Communications in Mass Spectrometry: RCM, 2003, v. 17, n. 14, p. 1573, doi. 10.1002/rcm.1087
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Comparison of conventional and enhanced mass resolution triple-quadrupole mass spectrometers for discovery bioanalytical applications.
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- Rapid Communications in Mass Spectrometry: RCM, 2003, v. 17, n. 8, p. 832, doi. 10.1002/rcm.985
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Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery.
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- Rapid Communications in Mass Spectrometry: RCM, 2003, v. 17, n. 1, p. 97, doi. 10.1002/rcm.876
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It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS.
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- Journal of Mass Spectrometry, 2011, v. 46, n. 6, p. 595, doi. 10.1002/jms.1921
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Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048).
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- Journal of Mass Spectrometry, 2008, v. 43, n. 4, p. 509, doi. 10.1002/jms.1341
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Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry.
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- Journal of Mass Spectrometry, 2003, v. 38, n. 10, p. 1081
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Microsample Determination of Lovastatin and its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/ Ionspray Tandem Mass Spectrometry.
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- Journal of Mass Spectrometry, 1997, v. 32, n. 4, p. 379, doi. 10.1002/(SICI)1096-9888(199704)32:4<379::AID-JMS461>3.0.CO;2-9
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Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column high-performance liquid chromatography/tandem mass spectrometry.
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- Rapid Communications in Mass Spectrometry: RCM, 2002, v. 16, n. 10, p. 944, doi. 10.1002/rcm.648
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In vitro metabolite identification using fast gradient high performance liquid chromatography combined with tandem mass spectrometry.
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- Rapid Communications in Mass Spectrometry: RCM, 2002, v. 16, n. 3, p. 212, doi. 10.1002/rcm.556
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Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry.
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- Rapid Communications in Mass Spectrometry: RCM, 2001, v. 15, n. 24, p. 2481, doi. 10.1002/rcm.479
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Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery.
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- Rapid Communications in Mass Spectrometry: RCM, 2001, v. 15, n. 5, p. 335, doi. 10.1002/rcm.235
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Determination of brain and plasma drug concentrations by liquid chromatography/tandem mass spectrometry.
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- Rapid Communications in Mass Spectrometry: RCM, 2000, v. 14, n. 19, p. 1729, doi. 10.1002/1097-0231(20001015)14:19<1729::AID-RCM85>3.0.CO;2-5
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Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry.
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- Rapid Communications in Mass Spectrometry: RCM, 2000, v. 14, n. 15, p. 1384, doi. 10.1002/1097-0231(20000815)14:15<1384::AID-RCM32>3.0.CO;2-#
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Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples.
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- Rapid Communications in Mass Spectrometry: RCM, 1999, v. 13, n. 20, p. 1991, doi. 10.1002/(SICI)1097-0231(19991030)13:20<1991::AID-RCM743>3.0.CO;2-2
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Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability.
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- Rapid Communications in Mass Spectrometry: RCM, 1999, v. 13, n. 10, p. 901, doi. 10.1002/(SICI)1097-0231(19990530)13:10<901::AID-RCM583>3.0.CO;2-5
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High-throughput cassette assay for drug stability measurement in plasma using direct HPLC-MS/MS.
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- Spectroscopy: An International Journal, 2003, v. 17, n. 2/3, p. 511, doi. 10.1155/2003/657571
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