We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Down Syndrome Associated Childhood Acute Eryhtroid Leukemia with Acquired Ring Chromosome 7: A Rare Case Report.
- Authors
Zakaria, Amalina; Ismail, Siti Mariam; Yunus, Nazihah Mohd; Sulong, Sarina; Ankathil, Ravindran
- Abstract
Background: Down syndromae (DS) has been recognized as one of the most important leukemia-predisposing syndromes especially acute myeloid leukemias (AML). Patients with DS-AML have unique clinical features and significant differences in treatment response and toxicity profiles compared to AML patients without DS. Objective: We present a rare case of a DS child with co-occurrence of a rare form of AML i.e. acute erythroid leukemia (AEL) and acquired ring chromosome 7. Method: A case report. Conclusion: Despite the presence of ring chromosome in leukemias is associated with poor prognosis, this case had a good outcome and is still alive 48 months after diagnosis. She achieved complete remission after completion of intensive chemotherapy.
- Subjects
THERAPEUTIC use of antineoplastic agents; BIOPSY; CANCER chemotherapy; CHROMOSOME abnormalities; DAUNOMYCIN; ETOPOSIDE; RARE diseases; DOWN syndrome; CYTARABINE; ACUTE erythroid leukemia; DISEASE complications
- Publication
International Medical Journal, 2020, Vol 27, Issue 6, p703
- ISSN
1341-2051
- Publication type
Article