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- Title
The Association between Arterial Stiffness and Risk of Coronary Artery Disease in a Community-Based Population.
- Authors
Yun Zhang; Ping Ye; Leiming Luo; Yongyi Bai; Ruyi Xu; Wenkai Xiao; Dejun Liu; Hongmei Wu
- Abstract
Aim: Arterial stiffness is well known as an important risk factor for coronary artery disease. In this study, we aimed to investigate the association between caPWV and risk of coronary artery disease (CAD), and the interaction between pulse wave velocity (PWV) and other potential risk factors of CAD. Methods: A community-based cross-sectional study was conducted for subjects living in Beijing, China. We collected 213 subjects with coronary artery disease and 1266 subjects without CAD between September 2007 and January 2009 in a community center of Beijing. A multivariate logistic regression analysis was carried out to assess the odds ratios of factors related to CAD. Results: We found CAD subjects were more likely to have a higher BMI, fasting glucose, uric acid, LDL cholesterol, hs-CRP, cfPWV and caPWV (P < 0.05), and CAD subjects had a significantly lower HDL cholesterol levels (P < 0.05). Moreover, the proportion of hypertension in CAD subjects was significantly higher than non-CAD subjects. The multiple logistic regression analysis showed that hypertension, higher uric acid, hs-CRP, cfPWV and caPWV levels significantly increased the risk of CAD, with ORs (Cl) of 1.47(1.25-1.74), 1.17(1.01-1.26), 1.35(1.10-1.67), 1.15(1.09-1.19) and 1.07(1.01-1.15), respectively. Higher HDL cholesterol was significantly associated with reduced risk of CAD, with ORs (Cl) of 0.58(0.40-0.83). In addition, cfPWV had significant association with age, hypertension, LDL cholesterol, with Pearson's coefficients of 0.166, 0.074, and 0.03, respectively. Conclusion: This study demonstrates that the cfPWV and caPWV is independently associated with significant CAD, and cfPWV has significant correlation with age and hypertension. CfPWV and caPWV may be used as a practical tool for predicting the risk of CAD.
- Subjects
CORONARY heart disease risk factors; ARTERIES; TIME; MULTIPLE regression analysis; CROSS-sectional method
- Publication
International Medical Journal, 2016, Vol 23, Issue 5, p518
- ISSN
1341-2051
- Publication type
Article