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- Title
New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H<sub>2</sub> synthases<sup>*</sup>.
- Authors
Aronoff, David M.; Oates, John A.; Boutaud, Olivier
- Abstract
The article offers a look on the new insights into the mechanism of action of acetaminophen, a drug used as antipyretic and analgesic agent. According to the authors, the pharmacologic characteristics of acetaminophen reflect its inhibition of the two prostaglandin H2 synthases. However, higher concentrations of lipid and nonlipid hydroperoxides within activated leukocytes and platelets prevent acetaminophen from affecting such processes as inflammation and platelet thrombosis.
- Subjects
ACETAMINOPHEN; ANALGESICS; ACETANILIDE; PROSTAGLANDINS; INFLAMMATORY mediators; THROMBOSIS
- Publication
Clinical Pharmacology & Therapeutics, 2006, Vol 79, Issue 1, p9
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1016/j.clpt.2005.09.009