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- Title
Solid Pseudopapillary Neoplasm Collides With a Well-Differentiated Pancreatic Endocrine Neoplasm in an Adult Man.
- Authors
Yan, Shirley X.; Adair, Carol F.; Balani, Jyoti; Mansour, John C.; Gokaslan, Sefik T.
- Abstract
Objectives: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, clinicopathologically distinct neoplasm with a tendency to affect young women. The histogenesis of SPN is not well defined. Pancreatic endocrine neoplasms (PENs) are also uncommon tumors of the pancreas. Methods: Our comprehensive review of the literature did not yield any reported cases of collision tumors of the above two neoplasms. We report a case of such a collision tumor in a 45-year-old man. Results: This tumor was an incidental finding on computed tomography, followed by fine-needle aspiration confirmation of a tumor that was initially diagnosed as an SPN only. A histologic examination of a 2.1-cm mass following distal pancreatectomy revealed a 0.7-cm PEN partly engulfed by an SPN. The tumors showed different morphologic and immunohistochemical features, confirming the presence of a collision tumor. Conclusions: A comparative analysis of immunoprofiles of these tumors yielded interesting findings, enabling us to postulate that SPNs may originate from a multipotential primordial cell that may follow different differentiation pathways, such as endocrine, epithelial, and acinar. The ultrastructures and immunophenotypic characteristics appear to support this hypothesis.
- Subjects
TUMORS; PATHOLOGY; ENDOCRINE gland tumors; MULTIPLE endocrine neoplasia; PANCREATIC cancer
- Publication
American Journal of Clinical Pathology, 2015, Vol 143, Issue 2, p283
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1309/AJCP75RYRMWKNQVE