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- Title
Night shift work job exposure matrices and urinary 6-sulfatoxymelatonin levels among healthy Chinese women.
- Authors
Bu-Tian Ji; Yu-Tang Gao; Xiao-Ou Shu; Gong Yang; Kai Yu; Shou-Zheng Xue; Hong-Lan Li; Linda M. Liao; Blair, Aaron; Rothman, Nathaniel; Wei Zheng; Wong-Ho Chow
- Abstract
Objective: Six-sulfatoxymelatonin (aMT6s) is a primary urinary metabolite of melatonin. We examined the association between aMT6s levels and shift work estimated by a job exposure matrix (JEM) among healthy participants of the Shanghai Women's Health Study. Methods: Creatinine-adjusted aMT6s levels were measured in the urine samples of 300 women and related to JEM shift work categories. Results: Adjusted geometric means of aMT6s levels from urine samples collected before 08:00 hours were lower among persons holding nighttime shift work jobs. The adjusted aMT6s levels (ng/mg creatinine) were 8.36 [95% confidence intervals (95% CI) 4.47-15.6], 6.37 (95% CI 3.53-11.5), 6.20 (95% CI 3.33-11.5), 3.81 (95% CI 2.02-7.19), and 3.70 (95% CI 1.92-7.11) from the lowest (never held a shift work job) to the highest (current job likely involved all-night shift work) shift work JEM scores (P=0.05). Conclusion: Our results indicate that night shift work JEM scores were significantly and inversely associated with aMT6s levels in early morning spot urine samples collected between 07:00-08:00 hours.
- Subjects
WOMEN'S health; NIGHT work; URINALYSIS; METABOLITE analysis; MELATONIN; MATRICES (Mathematics); CREATININE
- Publication
Scandinavian Journal of Work, Environment & Health, 2012, Vol 38, Issue 6, p553
- ISSN
0355-3140
- Publication type
Article
- DOI
10.5271/sjweh.3322