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- Title
Postradiation Synovial Sarcoma of the Common Bile Duct: A Previously Unreported Anatomic Site.
- Authors
Herrera-Goepfert, Roberto
- Abstract
Synovial sarcoma is a ubiquitous neoplasm predominantly affecting soft tissues of young adults of any gender; few cases have been described in the digestive system, mostly in the stomach. The (X;18)(p11.2; q11.2) translocation yields unique SS18-SSX fusion genes. Synovial sarcoma has been related to radiotherapy, but no synovial sarcoma has been associated with the digestive system. This article describes the case of a synovial sarcoma arising along the extrahepatic biliary tree, 10 years after the application of an abdominal radiotherapy schedule due to a retroperitoneal metastatic seminoma in a male who developed progressive obstructive jaundice. Ninety percent of the analyzed cells carried the SS18 gene with separation of sequences, thus denoting a translocation. There are only 8 post-radiotherapy synovial sarcomas that have been reported previously, and this is the first report of a radiotherapy-related synovial sarcoma arising from the extrahepatic biliary tree, and the second case described in this anatomic region.
- Subjects
OBSTRUCTIVE jaundice; RADIOTHERAPY; CHROMOSOMAL translocation; IONIZING radiation
- Publication
International Journal of Surgical Pathology, 2018, Vol 26, Issue 5, p469
- ISSN
1066-8969
- Publication type
Case Study
- DOI
10.1177/1066896917752863