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- Title
Crosstalks between helminthes and microbiota to improve gut health.
- Authors
Elwakil, H. S.
- Abstract
Intestinal helminths are potent regulators of their host's immune system and can protect against Inflammatory bowel disease. This anti-inflammatory activity remains largely unknown. Is it purely intrinsic to helminths, or whether it also involved cross interaction with the local microbiota? Microbiota and helminths have coevolved within the mammalian host. Both have common strategies of establishing a new homeostasis in the host intestinal tract. These strategies include regulating host immunity to permit their survival through the induction of suppressive regulatory T cells (Tregs). Also, Short-Chain Fatty Acids (SCFAs) may be a possible another common pathway shared by microbiota and helminths. SCFAs are microbial metabolite that are derived from microbial fermentation of dietary fibers in the colon. Similarly, some helminth infection leads to SCFAs elevation in human. SCFAs can potentiate T regs generation and IL-10 production in the periphery. Dissecting the multidirectional interactions among intestinal microbes, helminth parasites and their host immune system will hopefully enable the design of new therapeutic strategies to treat metabolic and inflammatory diseases.
- Subjects
SUPPRESSOR cells; SHORT-chain fatty acids; INFLAMMATORY bowel diseases; GUT microbiome; HELMINTH hosts
- Publication
QJM: An International Journal of Medicine, 2020, Vol 113, pi202
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcaa060.007