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- Title
Effects of vitamin A, C and E, or omega-3 fatty acid supplementation on the level of paraoxonase and arylesterase activity in streptozotocin-induced diabetic rats: an investigation of activities in plasma, and heart and liver homogenates.
- Authors
Zarei, Mahnaz; Fakher, Shima; Seyed Mohammad Bagher Tabei; Mohammad Hassan Javanbakht; Hoda Derakhshanian; Payam Farahbakhsh-Farsi; Mohammad Reza Sadeghi; Ebrahim Mostafavi; Mahmoud Djalali; Tabei, Seyed Mohammad Bagher; Javanbakht, Mohammad Hassan; Derakhshanian, Hoda; Farahbakhsh-Farsi, Payam; Sadeghi, Mohammad Reza; Mostafavi, Ebrahim; Djalali, Mahmoud
- Abstract
<bold>Introduction: </bold>This study was designed and conducted to evaluate the effects of vitamin A, C and E supplementation, and omega-3 fatty acid supplementation on the activity of paraoxonase and arylesterase in an experimental model of diabetes mellitus.<bold>Methods: </bold>A total of 64 male Sprague Dawley® rats, each weighing 250 g, were randomly distributed into four groups: (a) normal control; (b) diabetic control; (c) diabetic with vitamin A, C and E supplementation; and (d) diabetic with omega-3 fatty acid supplementation. The animals were anaesthetised after four weeks of intervention, and paraoxonase and arylesterase activity in blood plasma, and liver and heart homogenates were measured.<bold>Results: </bold>Arylesterase activity in the heart and liver homogenates was significantly lower in the diabetic control group than in the normal control group (p < 0.01). Vitamin A, C and E supplementation, and omega-3 fatty acid supplementation significantly increased liver arylesterase activity (p < 0.05). No significant change was observed in paraoxonase activity and other investigated factors.<bold>Conclusion: </bold>Vitamin A, C and E, or omega-3 fatty acid supplementation were found to increase liver arylesterase activity in streptozotocin-induced diabetic rats. These supplements may be potential agents for the treatment of diabetes mellitus complications.
- Subjects
PARAOXONASE; TREATMENT of diabetes; DIABETES complications; OMEGA-3 fatty acids; LABORATORY rats; VITAMIN A; VITAMIN C; VITAMIN E; DIET therapy for diabetes; ANIMAL experimentation; COMPARATIVE studies; DIABETES; DIETARY supplements; ESTERASES; LIVER; RESEARCH methodology; MEDICAL cooperation; MYOCARDIUM; RATS; RESEARCH; VITAMINS; EVALUATION research
- Publication
Singapore Medical Journal, 2016, Vol 57, Issue 3, p153
- ISSN
0037-5675
- Publication type
journal article
- DOI
10.11622/smedj.2015102