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- Title
Does statin therapy impact the proximal aortopathy in aortic valve disease?.
- Authors
Gross, T Sequeira; Naito, S; Neumann, N; Petersen, J; Kuntze, T; Reichenspurner, H; Kodolitsch, Y von; Girdauskas, E
- Abstract
Background Studies have demonstrated that statin therapy decreases the growth rate of abdominal aneurysms. However, the effect of statin therapy on the proximal aortic disease has not been sufficiently elucidated. Aim We aimed to analyse the association between statin treatment and the severity of proximal aortopathy in patients with aortic valve disease. Design Cross-sectional study. Methods We prospectively identified 458 patients who were referred for aortic valve surgery from 2008 to 2014. Pre-operative measurement of the proximal aorta was performed by TEE, CT or MRT scan. Data of dyslipidemia treatment was obtained by questionnaire. Results The mean ascending aortic diameter in the whole study population was comparable in patients with vs. without statin therapy (i.e. 42.7 mm vs. 43.6 mm, P = 0.46). Logistic regression analysis showed no significant association between statin therapy and proximal aortopathy ≥ 40 mm in the whole study group (OR = 0.69, P = 0.10). For the BAV sub-group, HDL (OR = 0.54, P = 0.038) and cholesterol levels (OR = 2.00, P = 0.038) were found significantly associated with the proximal aortic disease. In the BAV cohort, the statin users with target HDL levels presented a significantly smaller proximal aortic diameter (40.1 mm vs. 46 mm, P = 0.02). Conclusion Pre-operative statin therapy demonstrated no significant association with the expression of proximal aortopathy. However, more than 40% of the statin users presented uncontrolled lipid levels at the time of the study. In the BAV sub-group, the statins users with target HDL levels showed a significantly smaller ascending aorta diameter. Target HDL and cholesterol levels were strongly associated with proximal aortic dilation in BAV patients.
- Subjects
AORTIC diseases; AORTIC valve; CHOLESTEROL; DYSLIPIDEMIA; LOGISTIC regression analysis; THERAPEUTICS
- Publication
QJM: An International Journal of Medicine, 2018, Vol 111, Issue 9, p623
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcy129