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- Title
Clinical outcomes following unilateral adrenalectomy in patients with primary aldosteronism.
- Authors
Hannon, M. J.; Sze, W. C.; Carpenter, R.; Parvanta, L.; Matson, M.; Sahdev, A.; Druce, M. R.; Berney, D. M.; Waterhouse, M.; Akker, S. A.; Drake, W. M.
- Abstract
Background: In approximately half of cases of primary aldosteronism (PA), the cause is a surgically-resectable unilateral aldosterone-producing adrenal adenoma. However, long-termdata on surgical outcomes are sparse. Aim: We report on clinical outcomes post-adrenalectomy in a cohort of patients with PA who underwent surgery. Design: Retrospective review of patients treated for PA in a single UK tertiary centre. Methods: Of 120 consecutive patients investigated for PA, 52 (30 male, median age 54, range 30-74) underwent unilateral complete adrenalectomy. Blood pressure, number of antihypertensive medications, and serum potassium were recorded before adrenalectomy, and after a median follow-up period of 50 months (range 7-115). Recumbent renin and aldosterone were measured, in the absence of interfering antihypertensive medication, ⩾3months after surgery, to determine if PA had been biochemically cured. Results: Overall, blood pressure improved from a median (range) 160/95mmHg (120/80-250/150) pre-operatively to 130/80mmHg (110/70-160/93), P < 0.0001. 24/52 patients (46.2%) had cured hypertension, with a normal blood pressure postoperatively on no medication. 26/52 (50%) had improved hypertension. 2/52 patients (3.8%) showed no improvement in blood pressure post-operatively. Median (range) serum potassium level increased from 3.2 (2.3-4.7) mmol/l pre-operatively to 4.4 mmol/l (3.3-5.3) post-operatively, P < 0.0001). Median (range) number of antihypertensive medications used fell from 3 (0-6) pre- to 1 post-operatively (range 0-4), P < 0.0001. Conclusions: Unilateral adrenalectomy provides excellent long-term improvements in blood pressure control, polypharmacy and hypokalaemia in patients with lateralizing PA. These data may help inform discussions with patients contemplating surgery.
- Subjects
HYPERALDOSTERONISM; ADRENAL surgery; MEDICAL records; SERUM; BLOOD pressure
- Publication
QJM: An International Journal of Medicine, 2017, Vol 110, Issue 5, p277
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcw194