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- Title
Oscillatory Encoding of Visual Stimulus Familiarity.
- Authors
Kissinger, Samuel T.; Pak, Alexandr; Yu Tang; Masmanidis, Sotiris C.; Chubykin, Alexander A.
- Abstract
Familiarity of the environment changes the way we perceive and encode incoming information. Flowever, the neural substrates underlying this phenomenon are poorly understood. Here we describe a new form of experience-dependent low-frequency oscillations in the primary visual cortex (VI) of awake adult male mice. The oscillations emerged in visually evoked potentials and single-unit activity following repeated visual stimulation. The oscillations were sensitive to the spatial frequency content of a visual stimulus and required the mAChRs for their induction and expression. Finally, ongoing visually evoked θ (4 -8 Hz) oscillations boost the visually evoked potential amplitude of incoming visual stimuli if the stimuli are presented at the high excitability phase of the oscillations. Our results demonstrate that an oscillatory code can be used to encode familiarity and serves as a gate for oncoming sensory inputs.
- Subjects
VISUAL perception; VISUAL cortex physiology; EVOKED potentials (Electrophysiology); ACETYLCHOLINE; SILICON analysis; LABORATORY mice
- Publication
Journal of Neuroscience, 2018, Vol 38, Issue 27, p6223
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3646-17.2018