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- Title
Lac dye as a potential anti-neoplastic agent.
- Authors
Shamim, Gulsaz; Kumar Ranjan, Sanjeev; Pandey, Dev Mani; Sharma, Kewal Krishan; Ramani, Rangnathan; Ranjan, Sanjeev Kumar
- Abstract
<bold>Objective: </bold>Certain anthraquinone compounds are effectively used for treatment of cancer. The present study describes the inhibitory activity of lac dye, a mixture of polyhydroxy anthraquinone compounds (Laccaic acid A, B, C, D and E), produced by the Indian lac insect, Kerria lacca (Kerr).<bold>Materials and Methods: </bold>In vitro testing for anticancer activity of lac dye was done at four concentrations (10, 20, 40, 80 μg/ml) on ten human malignant cell lines including six human leukemia cell lines, U973, Raji, K562, Jurkat, MOLT 4 and HL60 using SRB assay.<bold>Results and Conclusion: </bold>Both crimson and yellow lac dye inhibits proliferation of Human leukemia cell lines, Raji, U937, K562, HL60 and Jurkat, therefore can be considered as a potential anticancer agent for leukemia.
- Subjects
ANTINEOPLASTIC agents; ANTHRAQUINONE dyes; CANCER treatment; LEUKEMIA; CELL lines; CELL proliferation; CELL physiology; ORGANIC compounds; PHARMACODYNAMICS
- Publication
Journal of Cancer Research & Therapeutics, 2016, Vol 12, Issue 2, p1033
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.155975