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- Title
Review: Bisphosphonates are modestly better than placebo for relieving painful bone metastases.
- Authors
Stockler, Martin
- Abstract
This article presents information on a study related to utilization of bisphosphonate agents for the management of pain secondary to bone metastases. Randomized controlled trials (RCTs) that included patients who had bone metastases with or without pain at enrollment, measured pain as an outcome, allowed antineoplastic therapy or rescue pain medications, and compared bisphosphonates with a control intervention. Using a random-effects model, meta-analysis of 5 RCTs showed greater pain relief with bisphosphonates than with placebo.
- Subjects
DIPHOSPHONATES; METASTASIS; META-analysis; PLACEBOS; BONE cancer; CANCER invasiveness
- Publication
ACP Journal Club, 2005, Vol 143, Issue 1, p31
- ISSN
1056-8751
- Publication type
Article
- DOI
10.7326/acpjc-2005-143-1-013