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- Title
Association of coronary heart disease with age-adjusted aortocoronary calcification in patients with familial hypercholesterolaemia.
- Authors
Jensen, J. M.; Gerdes, L. U.; Jensen, H. K.; Christiansen, T. M.; Brorholt-Petersen, J. U.; Faergeman, O.
- Abstract
<bold>Objectives: </bold>Existing algorithms of risk of coronary heart disease (CHD) do not pertain to patients with familial hypercholesterolaemia (FH), whose arteries have been exposed to hypercholesterolaemia since birth. We studied a cohort of FH patients to compare four diagnostic models of CHD: traditional risk factors of CHD (age, sex, cholesterol, hypertension, smoking and body mass index), cholesterol year score, and aortic as well as coronary calcium measured by spiral computed tomography (CT).<bold>Subjects: </bold>We invited 88 individuals with molecularly defined FH of whom 80 (91%) decided to participate.<bold>Results: </bold>Analysis of receiver operating characteristic curves showed that the age-adjusted coronary calcium score was more strongly associated with clinical manifestations of CHD than were traditional risk factors (P < 0.002), cholesterol year score (P << 0.0001), and the age-adjusted aortic calcium score (P < 0.0004).<bold>Conclusions: </bold>Age-adjusted coronary calcium score shows promise as an indicator of CHD in FH patients.
- Subjects
CORONARY disease; CALCIFICATION; HYPERCHOLESTEREMIA
- Publication
Journal of Internal Medicine, 2000, Vol 247, Issue 4, p479
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.2000.00630.x