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- Title
Synthesis, Antioxidative and Whitening Effects of Novel Cysteine Derivatives.
- Authors
Ha, Ji Hoon; Kim, Kyoung Mi; Jeong, Yoon Ju; Park, Young Min; Lee, Jae-Young; Park, Jino; Park, Soo Nam
- Abstract
Recently, development of biocompatibility functional cosmetic agents as antioxidant or whitening agent has increased. In this study, synthetic cysteine derivatives ( DBLS-21, -24, and -33) were developed containing syringic acid and cysteine moieties ( l-cysteine ethyl ester, N-acetyl cysteine methyl ester, and N-acetyl cysteine ethyl ester), and their antioxidative and whitening activities were evaluated. The cellular protective effect (τ50) of DBLS-21 was 51.1 min at 50 μM on 1O2 -induced hemolysis of erythrocytes. This activity was slightly higher than that of α-tocopherol (43.6 min) as a lipophilic antioxidant. In the melanogenesis inhibitory effect, DBLS-21, -24, and -33 was 1.6-, 1.8-, and 2.5-fold higher than arbutin, respectively. In particular, DBLS-21 and -33 was 112.8- and 6.1-fold higher than arbutin, respectively (293.4 μM) on tyrosinase inhibition activity ( IC50 ). But DBLS-24 had no tyrosinase inhibitory activity. These results suggest that cysteine derivatives possess potential for use as an antioxidant agent ( DBLS-21) and whitening agents (all derivatives) in cosmetics.
- Subjects
CHEMICAL synthesis; CYSTEINE; ETHYL esters; ANTIOXIDANTS; ARBUTIN; PHENOL oxidase; COSMETICS
- Publication
Bulletin of the Korean Chemical Society, 2017, Vol 38, Issue 1, p78
- ISSN
0253-2964
- Publication type
Article
- DOI
10.1002/bkcs.11050