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- Title
Distribution of Centromeric Proteins and PARP-1 during Mitosis and Apoptosis.
- Authors
Perdoni, Federica; Bottone, Maria Grazia; Soldani, Cristiana; Veneroni, Paola; Alpini, Claudia; Pellicciari, Carlo; Scovassi, Anna Ivana
- Abstract
A large complex of proteins, called CENPs, are associated with centromeric DNA. Some of them exhibit a cell cycle-related expression (e.g., CENP-E and -F) and are required for the transition from interphase to mitosis, whereas constitutive proteins (e.g., CENP-A, -B, -C, -G, and -H) reside permanently at the centromere and are essential for the correct kinetochore assembly. Poly(ADP-ribose) polymerase-1 (PARP-1), which plays an active role in many basic processes, was described as a possible regulator of CENPs. By multicolor immunofluorescence we therefore analyzed the distribution of PARP-1 and its interaction with CENP-B, -E, and -F during mitosis and apoptosis.
- Subjects
APOPTOSIS; CELL death; PROTEINS; KARYOKINESIS; CELL division
- Publication
Annals of the New York Academy of Sciences, 2009, Vol 1171, p32
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2009.04729.x