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- Title
Neighboring Genes Show Interchromosomal Colocalization after Their Separation.
- Authors
Dai, Zhiming; Xiong, Yuanyan; Dai, Xianhua
- Abstract
The order of genes on eukaryotic chromosomes is nonrandom. Some neighboring genes show order conservation among species, while some neighboring genes separate during evolution. Here, we investigated whether neighboring genes show interactions after their separation. We found that neighboring gene pairs tend to show interchromosomal colocalization (i.e., nuclear colocalization) in the species in which they separate. These nuclear colocalized separated neighboring gene pairs 1) show neighborhood conservation in more species, 2) tend to be regulated by the same transcription factor, and 3) tend to be regulated by the same histone modification. These results suggest a mechanism by which neighboring genes could retain nuclear proximity after their separation.
- Publication
Molecular Biology & Evolution, 2014, Vol 31, Issue 5, p1166
- ISSN
0737-4038
- Publication type
Article
- DOI
10.1093/molbev/msu065