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- Title
Synthesis of Some New 1,2,3,4-Tetrahydropyrimidine-2-thione and Their Thiazolo[3,2- a]pyrimidine, Thiazino and Benzothiazepine Derivatives.
- Authors
Fadda, A. A.; Bondock, S. B.; Khalil, A. M.; Tawfik, Eman H.
- Abstract
The starting N-(2-pyridyl)-6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide ( 4) was used as a key for the synthesis of new 1,2,3,4-tetrahydropyrimidine-2-thione and their thiazolo[3,2- a]pyrimidine, thiazino and benzothiazipen derivatives. The reaction of 4 with haloketones in ethanol catalyzed by base afforded the corresponding thiophenopyrimidine and pyrimidothiazipine derivatives 5, 6, 7, 8, 9, 10. and of 4 led to the pyrimidine derivatives 15 and 16, respectively. The preventative compounds were established on the basis of elemental and spectral data.
- Subjects
THIONES; CHEMICAL derivatives; HALOKETONES; CATALYSIS; PYRIMIDINES
- Publication
Journal of Heterocyclic Chemistry, 2013, Vol 50, Issue 4, p838
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1573