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- Title
Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis.
- Authors
Kotwal, Swati D.; Badole, Smita R.
- Abstract
Objective: Equisetum arvense has been used to treat bone diseases. The traditional supplementation of calcium and Vitamin D for osteoporosis patients is insufficient considering the rise in patients every year. We have observed that extending the calcium and Vitamin D supplement with L-lysine, L-proline, L-arginine, and L-ascorbic acid (N) positively affects bone mineralization in ovariectomized rat. Here, we report a further extension of the above supplement with E. arvense. Materials and Methods: The changes in serum biomarkers, bone mineral content, and femur bone histology were studied and compared to the standard drug for osteoporosis, namely raloxifene (RAL). Results: We report a significant change in formation and resorption markers of bone as well as in cortical bone thickness and trabecular width in N and N + EA groups. The treatment N + EA also restored lipid profile near to normal level compared to ovariectomized group. Conclusions: Treatment N + EA was found to be as effective as RAL in reversing the osteoporotic changes.
- Subjects
LABORATORY animals; TREATMENT of bone diseases; EQUISETUM; OSTEOPOROSIS prevention; RALOXIFENE
- Publication
Indian Journal of Pharmacology, 2016, Vol 48, Issue 3, p312
- ISSN
0253-7613
- Publication type
Article
- DOI
10.4103/0253-7613.182880