We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Glutamate measurement in Parkinson's disease using MRS at 3 T field strength.
- Authors
Kickler, Nils; Krack, Paul; Fraix, Valérie; Lebas, Jean-François; Lamalle, Laurent; Durif, Franck; Krainik, Alexandre; Rémy, Chantal; Segebarth, Christoph; Pollak, Pierre
- Abstract
Loss of nigral dopamine neurons in Parkinson's disease induces abnormal activation of glutamate systems in the basal ganglia. The purpose of this study was to assess these changes in the lentiform nucleus using MRS with optimized glutamate sensitivity ( TE-averaged method). Ten patients with Parkinson's disease and 10 healthy controls were examined. Compared with healthy controls, no significant differences in glutamate were measured in patients, but a trend to lower total creatine was observed. Copyright © 2007 John Wiley & Sons, Ltd.
- Publication
NMR in Biomedicine, 2007, Vol 20, Issue 8, p757
- ISSN
0952-3480
- Publication type
Article
- DOI
10.1002/nbm.1141