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- Title
Cardiac hyaluronan may be associated with the persistence of atrial fibrillation.
- Authors
Okada, Ayako; Kashima, Yuichiro; Tomita, Takeshi; Takeuchi, Takahiro; Oguchi, Yasutaka; Yoshie, Koji; Shoin, Wataru; Shoda, Morio; Nitta, Kenichi; Kuwahara, Koichiro; Imamura, Hiroshi
- Abstract
Hyaluronan (HA), a primary component of the extracellular matrix, is associated with several cardiovascular diseases. However, its precise cardiac origin and role in atrial fibrillation (AF) remain unclear. We investigated chamber-specific HA levels in patients with paroxysmal AF (PAF) or persistent AF (PSAF). The levels of HA, a diacron-reactive oxygen metabolite (dROM) as a marker for oxidative stress, at different cardiac sites, and peripheral brain natriuretic peptide (BNP) levels were measured in patients with PAF ( n = 50) or PSAF ( n = 35). HA levels in the coronary sinus (CS-HA) were significantly higher than those other sites, in both PAF and PSAF patients, and CS-HA levels were significantly higher in PSAF patients than in PAF patients [37.1 (interquartile range, 31.2-48.3) vs. 30.6 (23.7-40.2) pg/mL, P < 0.01]. CS-HA levels were correlated with CS-dROM levels and peripheral BNP levels in PSAF patients ( r = 0.417, P = 0.03 and r = 0.579, P < 0.001, respectively), but not in PAF patients ( r = −0.115, P = 0.421 and r = 0.048, P = 0.740, respectively). CS-HA levels were elevated in both PAF and PSAF patients and were correlated with cardiac oxidative stress and BNP levels in PSAF patients. Cardiac HA may be associated with the persistence of AF.
- Subjects
HYALURONIC acid; ATRIAL fibrillation; EXTRACELLULAR matrix; CARDIOVASCULAR diseases; OXIDATIVE stress
- Publication
Heart & Vessels, 2017, Vol 32, Issue 9, p1144
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-017-0972-9