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- Title
Reproducibility and correlation between quantitative and semiquantitative dynamic and intrinsic susceptibility-weighted MRI parameters in the benign and malignant human prostate.
- Authors
Alonzi, Roberto; Taylor, N. Jane; Stirling, J. James; d'Arcy, James A.; Collins, David J.; Saunders, Michele I.; Hoskin, Peter J.; Padhani, Anwar R.
- Abstract
Purpose: To assess the reproducibility of relaxivity- and susceptibility-based dynamic contrast-enhanced magnetic resonance imaging (MRI) in the benign and malignant prostate gland and to correlate the kinetic parameters obtained. Materials and Methods: Twenty patients with prostate cancer underwent paired scans before and after androgen deprivation therapy. Quantitative parametric maps for T1- and T2*-weighted parameters were calculated (Ktrans, kep,ve, IAUC60, rBV, rBF, and R2*). The reproducibility of and correlation between each parameter were determined using standard methods at both timepoints. Results: T1-derived parameters are more reproducible than T2*-weighted measures, both becoming more variable following androgen deprivation (variance coefficients for prostate Ktrans and rBF increased from 13.9%-15.8% and 42.5%-90.8%, respectively). Tumor R2* reproducibility improved after androgen ablation (23.3%-11.8%). IAUC60 correlated strongly with Ktrans, ve, and kep (all P < 0.001). R2* did not correlate with other parameters. Conclusion: This study is the first to document the variability and repeatability of T1- and T2*-weighted dynamic MRI and intrinsic susceptibility-weighted MRI for the various regions of the human prostate gland before and after androgen deprivation. These data provide a valuable source of reference for groups that plan to use dynamic contrast-enhanced MRI or intrinsic susceptibility-weighted MRI for the assessment of treatment response in the benign or malignant prostate. J. Magn. Reson. Imaging 2010;32:155-164. © 2010 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2010, Vol 32, Issue 1, p155
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.22215