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- Title
Antinuclear antibody-negative systemic lupus erythematosus in a case with pregnancy.
- Authors
Xie, Qibing; Liu, Yi; Yang, Nanping; Yin, Geng
- Abstract
We described a 30-year-old pregnant woman developing antinuclear antibodies (ANA)-negative systemic lupus erythematosus (SLE) accompanied with arthritis, malar rash, lymphopenia, autoimmune hemolytic anemia, pericardial and pleural effusion, proteinuria and seizures. All serum autoantibodies except anti-Ro antibody were negative. An artificially induced abortion was performed to prevent SLE deterioration. Steroid and cyclophosphamide therapy were effective for this patient. During the 2-year follow-up period, her ANA and other SLE-related autoantibodies in serum remained negative. This case suggests that ANA may not be required in the pathogenesis of SLE, even in the case with pregnancy, and ANA-negative SLE may also have a dangerous clinical course.
- Subjects
CASE studies; ANTINUCLEAR factors; PREGNANCY complications; LYMPHOPENIA; AUTOIMMUNE hemolytic anemia; PLEURAL effusions; PROTEINURIA
- Publication
Rheumatology International, 2012, Vol 32, Issue 10, p3273
- ISSN
0172-8172
- Publication type
Report
- DOI
10.1007/s00296-010-1487-1