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- Title
Association between vitamin D receptor gene polymorphisms and intervertebral disc degeneration: A meta-analysis.
- Authors
Chen, Lin; Zhao, Song; Niu, Feng; Bi, Gui-Bin
- Abstract
<bold>Background: </bold>Studies that have investigated the association between vitamin D receptor (VDR) gene polymorphisms and intervertebral disc degeneration (IDD) have yielded inconsistent results.<bold>Methods: </bold>To investigate the association between VDR gene polymorphisms and IDD, a systematic literature search for relevant published studies was performed on PubMed, Embase, Web of Science, Cochrane library, Wan-Fang, and CNKI databases. A random effects model was used for heterogeneous data; while a fixed effect model was used for homogenous data. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to evaluate the strength of the association.<bold>Results: </bold>We observed no association between VDR FokI, TaqI-ApaI polymorphisms and IDD. However, on subgroup analysis by ethnicity, VDR FokI mutation was associated with a significantly lower risk for IDD [dominant model: OR = 0.78, 95% CI = 0.65-0.93; heterozygote model: OR = 0.76, 95% CI = 0.63-0.92; allele model: OR = 0.86, 95% CI = 0.75-0.98] among Caucasians.<bold>Conclusion: </bold>These results suggest that the VDR FokI polymorphism may be associated with IDD among Caucasians. However, the association between VDR TaqI-ApaI polymorphisms and IDD in Asians is still not clear. Further well-designed studies are needed to arrive at a definitive conclusion.
- Subjects
INTERVERTEBRAL disk diseases; VITAMIN D receptors; GENETIC polymorphisms; GENETIC mutation; META-analysis
- Publication
Journal of Orthopaedic Science, 2017, Vol 22, Issue 2, p184
- ISSN
0949-2658
- Publication type
journal article
- DOI
10.1016/j.jos.2016.11.009