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- Title
Valorization of Wild-Type Cannabis indica by Supercritical CO 2 Extraction and Insights into the Utilization of Raffinate Biomass.
- Authors
Pattnaik, Falguni; Hans, Nidhi; Patra, Biswa R.; Nanda, Sonil; Kumar, Vivek; Naik, Satya Narayan; Dalai, Ajay K.
- Abstract
Supercritical CO2 extraction (SCCO2) extraction of cannabis oil from Indian cannabis (Cannabis indica) leaves was optimized through a central composite design using CO2 pressure (150–250 bar), temperature (30–50 °C) and time (1–2 h). From the regression model, the optimal CO2 pressure, extraction temperature and time were 250 bar, 43 °C and 1.7 h, respectively resulting in the experimental yield of 4.9 wt% of cannabis oil via SCCO2 extraction. The extract contained cannabidiol, tetrahydrocannabivarin, Δ9-tetrahydrocannabinol and Δ8-tetrahydrocannabinol as well as two terpenoids such as cis-caryophyllene and α-humulene. Besides SCCO2 extraction of cannabis oil, the raffinate biomass was utilized to extract polyphenols using water as the extraction medium. Cannabis oil and water extractive were investigated for their half-maximal inhibitory concentration (IC50) values, which were found to be 1.3 and 0.6 mg/mL, respectively. This is comparable to the commercially available antioxidant such as butylated hydroxytoluene with an IC50 value of 0.5 mg/mL. This work on SCCO2 extraction of cannabinoids and other valuable bioactive compounds provides an environmentally sustainable technique to valorize cannabis leaves.
- Subjects
CANNABIS (Genus); CANNABIDIOL; CARBON dioxide; BUTYLATED hydroxytoluene; BIOMASS; TERPENES
- Publication
Molecules, 2023, Vol 28, Issue 1, p207
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28010207