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- Title
Hydrogen Sulfide Biology and Its Role in Cancer.
- Authors
Khattak, Saadullah; Rauf, Mohd Ahmar; Khan, Nazeer Hussain; Zhang, Qian-Qian; Chen, Hao-Jie; Muhammad, Pir; Ansari, Mohammad Azam; Alomary, Mohammad N.; Jahangir, Muhammad; Zhang, Chun-Yang; Ji, Xin-Ying; Wu, Dong-Dong
- Abstract
Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H2S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H2S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H2S in different malignancies has been reported. The study summarizes the synthesis of H2S, its roles, signaling routes, expressions, and H2S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H2S in the scientific community.
- Subjects
HYDROGEN sulfide; BIOLOGY; BIOMOLECULES; BREAST; COLON cancer; NEURODEGENERATION; SCIENTIFIC community
- Publication
Molecules, 2022, Vol 27, Issue 11, p3389
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27113389