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- Title
Effects of Regioisomerism on the Antiproliferative Activity of Hydroxystearic Acids on Human Cancer Cell Lines.
- Authors
Calonghi, Natalia; Boga, Carla; Nitti, Patrizia; Telese, Dario; Bordoni, Silvia; Farruggia, Giovanna; Asaro, Fioretta; Grandi, Martina; Zalambani, Chiara; Micheletti, Gabriele
- Abstract
A series of regioisomers of the hydroxystearic acid (HSA) was prepared, and the effect of the position of the hydroxyl group along the chain on a panel of human cancer cell lines was investigated. Among the various regioisomers, those carrying the hydroxyl at positions 5, 7, and 9 had growth inhibitor activity against various human tumor cell lines, including CaCo-2, HT29, HeLa, MCF7, PC3, and NLF cells. 10-HSA and 11-HSA showed a very weak effect. 8-HSA did not show inhibitory activity in all cell lines. The biological role of 7-HSA and 9-HSA is widely recognized, while little is known about the effects of 5-HSA. Therefore, the biological effects of 5-HSA in HeLa, HT29, MCF7, and NLF cell lines were investigated using the Livecyte's ptychography technology, which allows correlating changes in proliferation, motility, and morphology as a function of treatment at the same time. 5-HSA not only reduces cell proliferation but also induces changes in cell displacement, directionality, and speed. It is important to characterize the biological effects of 5-HSA, this molecule being an important component of fatty acyl esters of hydroxy fatty acids (FAHFA), a class of endogenous mammalian lipids with noticeable anti-diabetic and anti-inflammatory effects.
- Subjects
CELL lines; FATTY acid esters; CELL proliferation; HYDROXYL group; CANCER cells
- Publication
Molecules, 2022, Vol 27, Issue 8, pN.PAG
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27082396