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- Title
Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl.
- Authors
González-Cortazar, Manáses; Maldonado-Abarca, Ana María; Jiménez-Ferrer, Enrique; Marquina, Silvia; Ventura-Zapata, Elsa; Zamilpa, Alejandro; Tortoriello, Jaime; Herrera-Ruiz, Maribel
- Abstract
Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy- 4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.
- Subjects
FLAVANONES; ANTIDEPRESSANTS; URSOLIC acid; GLUCOSIDES; MULTIPLE bonds (Chemistry); QUANTUM coherence
- Publication
Molecules, 2013, Vol 18, Issue 11, p13260
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules181113260