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- Title
A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction.
- Authors
Jun He; Guang Ouyang; Zhixiang Yuan; Rongsheng Tong; Jianyou Shi; Liang Ouyang
- Abstract
An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
- Subjects
RING formation (Chemistry); SCHIFF bases; AMINO acids; ORGANIC chemistry; HYDANTOIN
- Publication
Molecules, 2013, Vol 18, Issue 5, p5142
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18055142