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- Title
Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis.
- Authors
Nao, Naganori; Okagawa, Tomohiro; Nojiri, Naomi; Konnai, Satoru; Shimakura, Honami; Tominaga, Misono; Yoshida-Furihata, Hazuka; Nishiyama, Eri; Matsudaira, Takahiro; Maekawa, Naoya; Murata, Shiro; Muramatsu, Masamichi; Ohashi, Kazuhiko; Saito, Masumichi
- Abstract
Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3–9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.
- Publication
Archives of Virology, 2024, Vol 169, Issue 3, p1
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-024-05970-3