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- Title
Ultrasound evaluation of normal rhesus macaque fetal biometry and uteroplacental hemodynamics.
- Authors
D'Mello, Rahul J.; Lo, Jamie O.; Hagen, Olivia L.; Castro, Jenna N.; Graham, Jason A.; Frias, Antonio E.; Roberts, Victoria H. J.
- Abstract
Nonhuman primates are important preclinical models for translational, reproductive, and developmental science. Clinical evaluation of human fetal development is performed using standard sonographic‐derived fetal biometry, assessments of amniotic fluid, and uteroplacental hemodynamics. These noninvasive in utero measurements provide important information regarding fetal growth and pregnancy well‐being. Abnormalities in fetal growth, amniotic fluid volume, or placental vascular function are associated with placental insufficiency and adverse perinatal outcomes including stillbirth. The fetal biometric parameters most commonly assessed are biparietal diameter, head circumference, abdominal circumference, and femur diaphysis length. Evaluation of amniotic fluid volume includes measuring the fluid in four quadrants of the uterus to generate an Amniotic Fluid Index. Measures of uteroplacental hemodynamics typically include doppler assessment of the umbilical artery and ductus venosus, but can also include interrogation of the uterine artery and umbilical vein. In this study, we compile prenatal ultrasound data of fetal biometry, amniotic fluid measurements, and uteroplacental hemodynamics obtained from pregnancy studies conducted at the Oregon National Primate Research Center. The data included are from control unperturbed pregnant animals who have not undergone in utero experimental manipulations. This is the first report of comprehensive sonographic measurements following standardized clinical obstetric protocols utilized in rhesus macaques. The outcome is a large, prenatal ultrasound resource to be used by laboratory animal researchers in future nonhuman primate pregnancy studies for antenatal assessment. Research highlights: Nonhuman primates are important preclinical models for translational, reproductive, and developmental science.Clinical evaluation of human fetal development is performed using standard sonographic‐derived fetal biometry, assessments of amniotic fluid, and uteroplacental hemodynamics.Nomograms generated by this study can be used in nonhuman primate pregnancies to determine if there is concern for fetal growth restriction or placental insufficiency.This is the first report of comprehensive sonographic measurements following standardized clinical obstetric protocols utilized in rhesus macaques.
- Subjects
RHESUS monkeys; MACAQUES; AMNIOTIC liquid; FETAL growth retardation; UMBILICAL arteries; HEMODYNAMICS; BIOMETRY
- Publication
American Journal of Primatology, 2023, Vol 85, Issue 7, p1
- ISSN
0275-2565
- Publication type
Article
- DOI
10.1002/ajp.23504