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- Title
Cell-cycle checkpoints and cancer.
- Authors
Kastan, Michael B.; Bartek, Jiri
- Abstract
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.
- Subjects
CANCER treatment; GENES; NUCLEIC acids; GENETIC mutation; BIOCHEMICAL genetics; CELL cycle
- Publication
Nature, 2004, Vol 432, Issue 7015, p316
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature03097