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- Title
Using MRI derived observed to expected total lung volume to predict lethality in fetal skeletal dysplasia.
- Authors
Bulas, Dorothy I.; Fraser, Jamie L.; Cilli, Kate
- Abstract
A recent article in Pediatric Radiology by Mehollin-Ray and colleagues discusses the use of MRI-derived observed to expected total lung volume (O/E-TLV) to predict lethality in fetal skeletal dysplasia. The study found that an O/E-TLV <0.49 was a significant risk factor for poor outcome, with a sensitivity of 0.63 and specificity of 0.93. Additionally, a femur length to abdominal circumference (FL/AC) ratio of <0.129 was also a strong predictor of poor outcome. The authors suggest that these measures can provide valuable information for counseling families and planning deliveries when a skeletal dysplasia is not clearly diagnosed.
- Subjects
SKELETAL dysplasia; LUNG volume; RIB fractures; FIBROBLAST growth factor receptors; NUCLEOTIDE sequencing; FETAL MRI
- Publication
Pediatric Radiology, 2024, Vol 54, Issue 5, p854
- ISSN
0301-0449
- Publication type
Article
- DOI
10.1007/s00247-024-05893-w