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- Title
Effect of Pyridoxine Derivative B6NO on Transcription Factor Nrf2 Activity and Cytotoxic Properties of Doxorubicin In Vitro.
- Authors
Balakina, A. A.; Amozova, V. I.; Prikhodchenko, T. R.; Stupina, T. S.; Mishchenko, D. V.
- Abstract
The effect of a new pyridoxine derivative B6NO on doxorubicin cytotoxicity and Nrf2-dependent cellular processes in vitro was studied. Antioxidant B6NO enhances the cytotoxic effect of doxorubicin on tumor cells, which is associated with G2/M cell division arrest and an increase in activity of proapoptotic enzyme caspase-3. The antioxidant promotes intracellular accumulation and nuclear translocation of Nrf2 transcription factor in non-tumor and tumor cells. In non-tumor cells, B6NO increases the expression of antioxidant system proteins and reduces ROS generation in the presence of doxorubicin. In tumor cells, no activation of Nrf2-dependent processes occurs under the action of the antioxidant. Our findings demonstrate the prospect of further studies of pyridoxine derivatives as antioxidants to reduce adverse reactions during chemotherapy.
- Subjects
TRANSCRIPTION factors; DOXORUBICIN; PROTEIN expression; VITAMIN B6; NUCLEAR factor E2 related factor; CHEMOTHERAPY complications
- Publication
Bulletin of Experimental Biology & Medicine, 2024, Vol 176, Issue 5, p687
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-024-06091-2