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- Title
Depolarization of the Atrial Subepicardium in Rats with Experimentally Induced Pulmonary Hypertension.
- Authors
Smirnova, S. L.; Roshchevskaya, I. M.
- Abstract
Using an experimental model of pulmonary hypertension in rats (monocrotaline in a dose of 60 mg/kg), we revealed an additional focus of early excitation in the zone where the pulmonary veins enter the left atrium, in addition to the main focus in the sinoatrial node. Pulmonary hypertension leads to the formation of regions of early activation in the right and left atria and a significant change in the sequence of atrial depolarization. Propagation of independent excitation waves in the right and left atria increases heterogeneity of depolarization and leads to the formation of atrial arrhythmias.
- Subjects
PULMONARY hypertension; LEFT heart atrium; SINOATRIAL node; PULMONARY veins; ATRIAL arrhythmias; RATS; MONOCROTALINE; VASOCONSTRICTION
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 170, Issue 6, p741
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05145-z