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- Title
Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank.
- Authors
Jiao, Xue-Feng; Li, Hailong; Zeng, Linan; Yang, Huazhen; Hu, Yao; Qu, Yuanyuan; Chen, Wenwen; Sun, Yajing; Zhang, Wei; Zeng, Xiaoxi; Zhang, Lingli
- Abstract
Purpose: To examine the associations between use of statins and risks of various ovarian, uterine, and cervical diseases, including ovarian cancer, endometrial cancer, cervical cancer, ovarian cyst, polycystic ovarian syndrome, endometriosis, endometrial hyperplasia, endometrial polyp, and cervical polyp. Methods: We conducted a cohort study among female participants in the UK Biobank. Information on the use of statins was collected through verbal interview. Outcome information was obtained by linking to national cancer registry data and hospital inpatient data. We used Cox proportional hazards regression to examine the associations. Results: A total of 180,855 female participants (18,403 statin users and 162,452 non-users) were included. Use of statins was significantly associated with increased risks of cervical cancer (adjusted hazard ratio (HR), 1.55; 95% confidence interval (95% CI), 1.05–2.30) and polycystic ovarian syndrome (adjusted HR, 4.39; 95% CI, 1.68–11.49). However, we observed no significant association between use of statins and risk of ovarian cancer, endometrial cancer, ovarian cyst, endometriosis, endometrial hyperplasia, endometrial polyp, or cervical polyp. Conclusion: Our findings suggest that use of statins is associated with increased risks of cervical cancer and polycystic ovarian syndrome, but is not associated with increased or decreased risk of ovarian cancer, endometrial cancer, ovarian cyst, endometriosis, endometrial polyp, or cervical polyp.
- Subjects
RISK assessment; POLYPS; LIFESTYLES; CERVIX uteri tumors; OVARIAN tumors; QUESTIONNAIRES; INTERVIEWING; FISHER exact test; POLYCYSTIC ovary syndrome; DESCRIPTIVE statistics; CHI-squared test; ENDOMETRIAL tumors; ENDOMETRIOSIS; LONGITUDINAL method; STATINS (Cardiovascular agents); OVARIAN cysts; UTERINE diseases; SOCIODEMOGRAPHIC factors; CONFIDENCE intervals; DATA analysis software; PROPORTIONAL hazards models; NONPARAMETRIC statistics; DISEASE risk factors
- Publication
European Journal of Clinical Pharmacology, 2024, Vol 80, Issue 6, p855
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-024-03656-y