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- Title
Multiple Alpha Chain Loci for Human Haemoglobins: Hb J-Buda and Hb G-Pest.
- Authors
HOLLÁN, S. R.; SZELENYI, J. G.; BRIMHALL, B.; DUERST, M.; JONES, R. T.; KOLER, R. D.; STOCKLEN, Z.
- Abstract
IT is well established that at least two independent loci control the structure of human haemoglobin A1,2. Although the primary structure of the β-chain is determined by a single genetic locus, there are conflicting reports that the α-chain is controlled by one3 or two4,5 loci. We now describe genetic and chemical studies of a Budapest family which possess two abnormal α-chain haemoglobins, Hb J-Buda and Hb G-Pest, and review evidence for multiple loci for the α-chain.
- Publication
Nature, 1972, Vol 235, Issue 5332, p47
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/235047a0