We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat.
- Authors
Klaassen, Felix H.; de Voogd, Lycia D.; Hulsman, Anneloes M.; O'Reilly, Jill X.; Klumpers, Floris; Figner, Bernd; Roelofs, Karin
- Abstract
Avoidance, a hallmark of anxiety-related psychopathology, often comes at a cost; avoiding threat may forgo the possibility of a reward. Theories predict that optimal approach-avoidance arbitration depends on threat-induced psychophysiological states, like freezing-related bradycardia. Here we used model-based fMRI analyses to investigate whether and how bradycardia states are linked to the neurocomputational underpinnings of approach-avoidance arbitration under varying reward and threat magnitudes. We show that bradycardia states are associated with increased threat-induced avoidance and more pronounced reward-threat value comparison (i.e., a stronger tendency to approach vs. avoid when expected reward outweighs threat). An amygdala-striatal-prefrontal circuit supports approach-avoidance arbitration under threat, with specific involvement of the amygdala and dorsal anterior cingulate (dACC) in integrating reward-threat value and bradycardia states. These findings highlight the role of human freezing states in value-based decision making, relevant for optimal threat coping. They point to a specific role for amygdala/dACC in state-value integration under threat. A human fMRI study shows that defensive cardiac states moderate the neural computations of reward and threat value underlying approach-avoidance arbitration.
- Subjects
AMYGDALOID body; ARBITRATION &; award; CINGULATE cortex; PATHOLOGICAL psychology; BRADYCARDIA; DECISION making
- Publication
Communications Biology, 2024, Vol 7, Issue 1, p1
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-024-06267-6