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- Title
Triple-negative breast cancer in African-American women: disparities versus biology.
- Authors
Dietze, Eric C.; Sistrunk, Christopher; Miranda-Carboni, Gustavo; O'Regan, Ruth; Seewaldt, Victoria L.
- Abstract
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women of African origin. There is evidence that African-American women with TNBC have worse clinical outcomes than women of European descent. However, it is unclear whether survival differences persist after adjusting for disparities in access to health-care treatment, co-morbid disease and income. It remains controversial whether TNBC in African-American women is a molecularly distinct disease or whether African-American women have a higher incidence of aggressive biology driven by disparities: there is evidence in support of both. Understanding the relative contributions of biology and disparities is essential for improving the poor survival rate of African-American women with TNBC.
- Subjects
AFRICAN American women; BREAST cancer; GENETIC mutation; HEALTH equity; PUBLIC health
- Publication
Nature Reviews Cancer, 2015, Vol 15, Issue 4, p248
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc3896