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- Title
The emerging roles of YAP and TAZ in cancer.
- Authors
Moroishi, Toshiro; Hansen, Carsten Gram; Guan, Kun-Liang
- Abstract
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.
- Subjects
GENE regulatory networks; PDZ proteins; HOMEOSTASIS; NEOPLASTIC cell transformation; CANCER invasiveness
- Publication
Nature Reviews Cancer, 2015, Vol 15, Issue 2, p73
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc3876