The article presents research highlights from the field of melanoma research based on the original research paper "A multi-marker assay to distinguish malignant melanomas from benign nevi," by M. Kashani-Sabet et al. that appeared in the March 30, 2009 issue of "Proceedings of the National Academy of Science USA." Subjects discussed include biomarkers, diagnostic assays, melanocytic neoplasms, and the use of immunohistochemistry.