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- Title
REGULATION OF THE ENERGETIC FUNCTION AND REACTIVE OXYGEN SPECIES FORMATION IN MITOCHONDRIA BY DAIDZIN.
- Authors
Allaberganovich, Niyazmetov Bahodir; Rakhimjonovich, Abdullaev Gafurjon; Khushnutovna, Babadjanova Sayyora; Tajibayevich, Almatov Karim
- Abstract
In vitro assays, it was found that daidzin does not affect the respiratory function of mitochondria and the rate of Chance's respiratory control, but dose-dependent increases ADP/O ratio. This process is especially noticeable in the oxidation of succinate. Daidzin inhibits the processes of lipid peroxidation and the activity of lytic mitochondrial enzymes. This means that daidzin increasing bilayer areas of mitochondrial membranes, stabilizes the compactness of membranes. In this regard, the availability of exogenous phospholipase A2 cobra venom to the phospholipids of mitochondrial membranes is difficult.
- Subjects
MITOCHONDRIA; REACTIVE oxygen species; DAIDZIN; GLUTAMIC acid; COBRA venom factor
- Publication
European Science Review, 2018, Issue 3/4, p50
- ISSN
2310-5577
- Publication type
Article